Researchers used supramolecular nanoparticles to repair the brain’s vascular system and reverse Alzheimer’s in mice. Instead of carrying drugs, the nanoparticles themselves triggered natural clearance of amyloid-β proteins. This restored blood-brain barrier function and reversed memory loss. The results point to a revolutionary new path for treating neurodegenerative diseases.
  • Lemmyoutofhere@lemmy.caEnglish
    29·
    9 days ago

    “Only 1h after the injection we observed a reduction of 50-60% in Aβ amount inside the brain”

    Wow.

      • AbouBenAdhemEnglish
        27·
        9 days ago

        That article reports that a drug targeted at clearing amyloid proteins didn’t suffice to restore the brain’s waste-clearing functionality; this article reports that a drug targeted at repairing the blood-brain barrier does restore waste-clearing functionality (including amyloid proteins). So they’re not completely contradictory.

  • SolidShakeEnglish
    20·
    9 days ago

    If this goes to human trials and works and then gets approved for every patient I can only imagine the hundreds of thousands of debt this will put people and their families in. It’s awesome news, but the reality of it sucks

    • AbouBenAdhemEnglish
      25·
      9 days ago

      It looks like the research was done by academic and government-sponsored institutions in Spain and China, so hopefully it won’t just become a profit-making tool for the biotech industry.

    • FredselfishEnglish
      8·
      9 days ago

      This will be given to people like Trump. Us poors will not be given this drug.

      • zout@fedia.io
        8·
        9 days ago

        Let’s give it to Trump tomorrow, before his mind is gone so far that he can’t be held accountable anymore!

  • jordanlundEnglish
    7·
    9 days ago

    So, wait, we figured out how to give mice alzheimers and then cure it? 🤔

  • FauxPseudo English
    2·
    9 days ago

    Mice lie. Monkeys exaggerate. Ferrets are weasels.

    • MalReynolds@piefed.socialEnglish
      5·
      9 days ago

      Not nice Lie Mice lie.

      I normally don’t bother with typos, but this one changes meaning significantly, for those not in the know it’s a saying in biological / biomedical science about the relevance of animal testing results to humans, although I’m unfamiliar with the ferrets part, but it’s cool.

      Mice lie and Monkeys exaggerate. - On the use of non-human primates in HIV research, Stephen B Weiner PhD.